complexity, GMO, scientific arrogance

Not So Fast, Wannabe Baby Designers.

Nature strikes a decisive blow against human hubris.

The ability of CRISPR gene-editing technology to safely modify human embryos has been cast into doubt after several recent papers described massive disruptions to DNA in embryos subjected to editing. 

Each of the three papers, published this month without peer review on the preprint server bioRxiv, intended to edit only a single gene. But results showed large-scale, unintended DNA deletions and rearrangements in the areas surrounding the targeted sequence. . . .

“There’s no sugarcoating this,” Fyodor Urnov, a geneticist and CRISPR researcher at the University of California, Berkeley, who was not involved with the research, tells OneZero. “This is a restraining order for all genome editors to stay the living daylights away from embryo editing.”

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complexity, diseases, scientific arrogance, Whither Homo sapiens?

Cancer is the Devil at the Door.

The avenger of hubris. Every time we aspire to pry into the cell nucleus and pry out immortality, beauty, genius, perfection, cancer, the fear, the suspicion, the specter, the threat of it, bars our way. Like Lucifer serving God, cancer, that twisted gargoyle double arising out of self, steps into the path and says, Not so fast, Louie. It ain’t that simple.

The schadenfreude of being sure (I’d bet my nonexistent billions on it) that the tech billionaires working so feverishly on the research to immortalize themselves (and apotheosize their offspring) are going to die despite their best efforts is worth the price of having to die oneself.

 

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complexity, intelligence

Where Angels Fear to Tread

As a nonscientist with one big toe in advanced science (I have copyedited everything from molecular genetics to quantum physics, don’t ask me how), I get to make a fool of myself by talking about things I really don’t understand very well. Here’s one of them.

One of the limitations on our thinking about molecular biology may be that we have to give things discrete names to think about them, whereas “in nature” there are just various molecular modules that are repurposed, reassembled, “decorated,” and recycled in myriad ways. Many molecules that to us are distinct named entities serving distinct purposes are really very, very similar to each other, differing just by a methyl group, a charged side group or tail that makes the molecule interact or fold differently, a joining of peptides into a dimer or polymer, or . . . That means in a way the molecular traffic in cells may be LESS complicated than it looks to us. We envision many more distinct entities than there actually are in the protean stuff that multitasks the maintenance of life. The process of learning biochemistry and molecular biology may be a process of first identifying distinct molecules and later reconstructing the cross-functional kinships among them, which is at best backwards from the way life does it (and even “backwards” is too two-dimensional). Life is so much smarter than we are!

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